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Thus, the dichotomy of mHtt processing: while some modifications increase the toxicity of the protein, these more toxic forms are intermediates in the process leading to total degradation.
Biotransformation of a chemical primarily facilitates its excretion into urine or bile; however, certain chemicals are biotransformed into more toxic forms and, as a result, biotransformation of chemicals is not always beneficial.
The preventative measures of mercury need to start from the detection and removal of the elemental form as (i) it represents 66 94% of anthropogenic air emissions, (ii) is hard to detect/remove and (iii) it can travel over long distances globally before converting to more toxic forms (oxidized/organic mercury).
The PHS, a nonprofit organization that once sold crack pipes via vending machine to curb the spread of HIV and Hepatitis C, runs two programs in the area to help severe alcoholics refrain from drinking these more toxic forms of liquor.
It can be attributed to several factors, including: (1) SYN may inhibit proteasomal function and induces protein degradation failure when overloaded intracellularly; (2) SYN can be modified into more toxic forms by peroxynitrite, reactive oxygen species and/or other endogenous oxidative compounds, and aggravates nigrostriatal degeneration.
However, estrogen-mediated decreases of Aβ, even in its more toxic forms, do not correlate consistently with improved cognition.
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The concentration of inorganic arsenic — considered the more toxic form — in the rice grains was nearly three times greater under flooded conditions.
They also convert the chromium in C.C.A. into its more toxic form, hexavalent chromium, which is the subject of the movie "Erin Brockovich".
Mercury is an especially difficult problem in some Adirondack lakes because the acidic water converts it into a more toxic form.
This was the fact that heptachlor, after a short period in the tissues of animals or plants or in the soil, assumes a considerably more toxic form, known as heptachlor epoxide.
Researchers at Duke University who studied the weed between 1999 and 2004 in a controlled forest area near Chapel Hill, N.C., where high levels of CO2 are pumped into test plots, found that poison ivy not only grew more vigorously, but also produced a more toxic form of urushiol, the resin that causes its rash.
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