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Exact(7)
Thus, more toxic agents such as polymyxins have been used as alternative therapeutic drugs against multidrug-resistant Acinetobacter infections (5, 6 ).
Interactions between two or more toxic agents can produce lung damage by chemical-chemical interactions, chemical-receptor interactions or by modification, by a first agent, of the cell and tissue response to a second agent.
These organisms can be resistant to all of the currently available antimicrobial agents or remain susceptible only to older, potentially more toxic agents, such as polymyxins, leaving limited and suboptimal options for treatment [ 2].
We cannot rule out confounding from unaccounted risk factors, for example, other more toxic agents such as furans, dioxins, or coplanar PCBs that are bioaccumulated in parallel with DDT, cis-nonachlor, and oxychlordane.
Clinical practice may differ from clinical trial procedures as clinicians may reserve more toxic agents (amphotericin B) for salvage therapy of more severely ill patients who failed short courses of other therapies.
Multi-drug resistance in these two species is associated with increased mortality, and has become sufficiently problematic in some locations that alternative therapy using older and more toxic agents such as polymyxins is sometimes considered the best option [ 17- 19].
Similar(53)
Reports from in vitro toxicity studies have suggested that aggregated Aβ is more toxic agent than soluble Aβ in cultured neurons [1], [17], [18].
Opinions will differ as to which of the two parties involved in the poisonously bad date is the more toxic agent.
Microarray analysis with a highly focused set of genes is capable of discriminating between different classes of toxicants and has potential for differentiating highly noxious versus more subtle toxic agents.
More people in more places handling toxic agents create more opportunities for an accident or intentional misuse by an insider, Keith Rhodes, an investigator with the Government Accountability Office, said at a Congressional hearing in October.
The combination treatment was more toxic than the agents administered alone.
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