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In addition, focused analysis of candidate genes should increase the chances of uncovering associations worth pursuing, by the following 2 mechanisms: increased prior likelihood of association and more tolerant threshold to claim association (18, 19).
For the remaining candidate genes, we did not observe association in spite of the large number of samples assembled (the largest ever studied for most candidate genes) and the more tolerant threshold for significance allowed by the focused analysis.
The second mechanism, a more tolerant threshold for association, is related to a problem that affects all complex diseases: the effect sizes of most genetic factors are below an OR of 1.20, and therefore large sample sizes are required to identify association at the genome level.
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Moreover, it is more helpful and meaningful to understand the tolerant threshold values of Phragmites australis and Suaeda salsa to As stress to maintain wetland ecosystem health.
This low mortality threshold was chosen in order to minimize the effect of the artificial selection of particular genotypes more tolerant to the insecticide during exposure.
"Your psyche gets more tolerant".
Things were more tolerant.
Democrats are more tolerant of bigger government.
Now the government is far more tolerant.
Foreigners are just more tolerant of corruption.
We are self-evidently more tolerant.
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