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The second step, oxidation of retinaldehyde to RA, is carried out by retinaldehyde dehydrogenases (Raldh or Aldh), which have more tissue specific expression patterns [21], [22], [23], [24], [25].
The common features of cancer include uncontrolled cell growth, reduction in apoptosis, and loss of cell cycle regulation, while other features are more tissue specific and thus differentiate them and their chemotherapies.
Furthermore, genes at distal position display more tissue specific expression than those at more proximal position.
Notably, some fusion transcripts are more tissue specific than non-fusion transcripts, and are translated into proteins [ 5].
On average they are expressed at lower levels, tend to be more tissue specific, evolve at faster rates, and are of relatively recent origins [ 22].
Figure 4 highlights that all 19055 genes follow the trend explained above, and that the more tissue specific groupings follow that trend but with lower NXScore peaks.
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The higher the tissue specificity index of a gene, the more tissue-specific its expression pattern is.
Moreover, they tend to be more tissue-specific, unable to turn into all sorts of cells.
Therefore, we showed that mouse Cyp19A1 contains more tissue-specific first exons than previously thought and displays a similar genomic organization to human CYP19A1.
As the embryo becomes older, p53-mediated response to stressors becomes weaker and more tissue-specific.
Finally, we have to note that there are probably many more tissue-specific editing sites than those identified in this work for the following reasons.
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