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Doctors testing patients for prostate cancer can significantly increase the number of cases they spot by taking more tissue samples, a recent study found.
The more tissue samples, the more we can make inferences from the data.
Mr Shaw said a template biopsy, which looks at more tissue samples than the usual prostate biopsy, should be included.
Analyzing more tissue samples would clarify the effect of gene length on transcriptional noise.
We are at present collecting more tissue samples for further investigation.
With more tissue samples examined, we can have more robust conclusions and perform the studies with insight into miRNA regulation.
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The eight transcripts whose expression was not validated could be false positives; however, we note that these, and even more lowly expressed lincRNAs, may yet be detected upon closer inspection and examination of more restricted tissue samples.
The current practice of repeated PSA testing, lower PSA thresholds triggering biopsies, obtaining more tissue biopsy samples, and repeating biopsies after initial negative findings increases detection of smaller volume indolent cancers.
All experiments were performed with three or more independent tissue samples.
Unexpectedly, the DHA-metabolite 17-HDHA was significantly higher in colon tissues from mice three days after DSS exposure) and was increased even more in tissue samples from mice treated with ASA.
Given the small amount of intra-species variability we observed in RNA-seq and methylation relative to other tissues, we expect to have greater power to detect small, statistically significantly inter-species differences that would have been missed by studies that consider more variable tissue samples.
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