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As shown previously [16] and here in Figure 8, 3R tau is able to form a range of structures from wide loosely coiled paired helical filaments (Figure 8A) to more tightly coiled straight filaments (Figure 8B) when assembled with heparin.
It is also difficult to say whether high-reactive people are aware, more generally, that their brains are more tightly coiled than other people's.
Of great interest is the general trend of increasing involution (more tightly coiled shells as shown by the decreasing UWI, Figure 6).
The persistent increasing involution (i.e. more tightly coiled whorls toward a closed umbilicus) coupled with the oxyconic shell as displayed by the auguritids and pinacitids is surely one of the most frequently observed large-scale morphological evolutionary trends among ammonoids [ 27, 28, 31- 33, 38, 39, 66, 136- 139].
Among the documented parallel morphological evolutionary trends, the most important are: increasing involution (more tightly coiled whorls toward a closed umbilicus); development of an oxyconic shell (more compressed shell and/or more acute venter); larger shell diameters (body size); and the terminal acquisition of an umbilical lid.
"There were two more evolutionary trends that coincided with the increasingly more tightly coiled shells: The size of the embryonic shells shrank increasingly over time the hatchlings became smaller and smaller.
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The '08 Vine Hill is more austere and tightly coiled than the McCrea, while the '08 Hudson is richer in texture, with an almost briny flavor, and the '08 Stone Flat is tangy, with a waxy, lanolin texture and beautiful mineral flavors.
The 2004's, we hoped, would have more of the fresh, tightly coiled hallmarks of classic Chablis, like the 2002's and the 2000's, the two best recent Chablis vintages.
'We Belong Together' doesn't have a guest rapper, or a hard-hitting beat, but Ms. Carey's tricky vocal lines give the song more propulsion than you'd expect, with tightly coiled counter-rhythms that tug against the beat".
With its mocking eyes and air of tightly coiled, evangelical malice, the result looks more like a depiction of a devil than a sober investigative tool.
It is important to note that the gene activation of the reporter plasmid was expected to be higher than the activation of endogenous genes because endogenous genes are tightly coiled into nucleosomes while reporter plasmids are not, thus making the reporter plasmid more prone to being transcribed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com