Sentence examples for more therapeutically relevant from inspiring English sources

Clinical trials, which have established that the approach is safe, are now being designed to address more therapeutically relevant issues.

Although CB HSCs are relatively easier to manipulate in vitro, harbor a higher proliferative capacity and are more susceptible to gene transduction [5], [6], adult HSCs are more therapeutically relevant for human gene therapy applications.

Because the high degree effects are more therapeutically relevant than the low degree of effects, the additional weighted average CI (CIwt) was calculated, which uses the formula: CIwt  =  [CI50 + 2CI75 + 3CI90 + 4CI95]/10, where CI50, CI75, CI90, CI95 are the CI values at 50 %, 75 %, 90 % and 95nhibition, respectively.

We thus investigated a possible similar potentiating effect using a more therapeutically relevant way for interfering with netrin-1.

To model this result in a more therapeutically relevant system, we treated Col4a1 +/mut cells with 4PBA.

To examine the effects of more therapeutically relevant stressors, MCF-7 cells were exposed to 1 μM doxorubicin for 24 hours before RNA extraction.

There are thought to be more than 500 therapeutically relevant GPCRs out of a total of over 700 identified to date, although only one, rhodopsin, has been the subject of a full 3D X-ray crystallography study.

Over the past few years, there have been advances in the management of NETs, which have included clearer characterisation, more specific and therapeutically relevant diagnosis, and improved treatments.

Our model, which is more physiological and therapeutically relevant, should be useful for future studies aiming to unravel the complex sets of interactions between pro- and anti-apoptotic Bcl-2 family members ultimately leading to MOMP, and thereby influence drug design to restore the mitochondrial pathway in cancer cells where MOMP is blocked.

CYP2D6 is one of most important CYP450 enzyme required for the metabolism of more than 30% of therapeutically relevant drugs, including antidepressants and antipsychotics [ 138, 139].

The survival advantage was even more dramatic (P⩽0.005) at 50 000 n M, a therapeutically relevant concentration within the range of the peak plasma levels achieved following bolus gemcitabine chemotherapy (De Pas et al, 2000; Fogli et al, 2002).