More than 30 randomized, controlled studies have found that exposure therapy and other cognitive behavioral therapies, most of which use exposure, are effective.
The program treats its patients using cognitive behavioral therapy, which has been shown to be superior to other therapies in more than 30 randomized, controlled studies, Dr. Halmi said.
After more than forty randomized trials evaluating the effects of SDD, there is strong evidence that SDD indeed reduces incidences of ICU-acquired respiratory tract infections (van Saene et al., 2003).
16 The glucose-lowering effects of vildagliptin have been investigated in more than 20 randomized, controlled clinical trials, with durations ranging from 12 to 104 weeks, involving >20,000 patients.
There is evidence from more than one randomized controlled trial to support the lack of utility with the use of recombinant activated factor VII (rVIIa) for the treatment of bleeding in blunt trauma or penetrating trauma patients [ 16- 18].
The authors agree that some uncertainty remains and concede that their analysis is based only on observational studies rather than on more reliable randomized controlled studies like those used to test new drugs.
However, in a recent analysis of the Diabetes Prevention Program (DPP), a randomized controlled trial (RCT) of more than 3,000 adults randomized to receive a program of intensive lifestyle modification, metformin treatment, or placebo control intervention, we examined the association of 34 established T2D loci with history of GDM, response to intervention, and indices of β-cell function.
There were six trials randomizing more than 500 (including three randomizing more than 1,000) children, all published since 2001.
Here we describe the baseline characteristics and treatment of the more than 8400 patients randomized in PARADIGM-HF, comparing these with both SOLVD-T and more contemporary drug and device trials in HF-REF.
10 The most recent EBCTCG overview analysis, published in 2012, includes treatment results from more than 20,000 women randomized to a taxane compared with a nontaxane-containing regimen, and found an improvement in recurrence-free survival (RFS) (hazard ratio [HR], 0.83; P < 0.00001) with the addition of a taxane to adjuvant chemotherapy.
