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Exact(9)
Plasma concentrations of TAK-438 increased slightly more than dose proportionally.
Mean AUC0 inf and Cmax on Day 7 increased slightly more than dose proportionally over the range 10 40 mg.
In addition TV-1106 increased more than dose proportionality but IGF1 reached a plateau between 50 and 100 mg.
In Part A, mean AMG 108 serum concentration-time profiles generally exhibited nonlinear PK, and serum concentrations increased more than dose proportionately.
AUC0 7 was more than dose proportional to MEDI-546 dose from 0.3 to 1.0 mg/kg/week, and proportional from 1.0 to 5.0 mg/kg/week.
Although there was a dose-proportional increase in maximum observed concentration, the increase in area under the curve was more than dose proportional.
Similar(51)
The systemic exposure (Cmax and AUC) increased in a more-than-dose-proportional manner.
This is consistent with the more-than-dose proportionality detected using the ANOVA model.
Further, sb-paclitaxel displays more-than-dose-proportional increases in systemic drug exposure over a narrow dose range [ 11– 11].
The PK exposure was more than dose-proportional.
After single oral administration to dogs, the systemic exposure increased more than dose-proportionally.
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