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Furthermore, more primitive reflexes were found in the more terminal stages of AD [ 11].
Abundant abnormal PrP became apparent in both the spinal cord and brain only between 90 to 120 days after ic inoculation and >170 days after ip inoculation.. Cerebral sections showed focal deposits of pathologic PrP in regions with spongiform changes at these more terminal stages as shown in Figure 1.
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The distribution of PrPSc in the spleen was examined further in two more terminal disease-stage BSE-affected cattle, numbers 5499 and 5468.
As CMV is known to drive the whole T-cell compartment towards a more terminal differentiation stage (Fletcher et al., 2005), we wondered if phenotype and functionality of the tuberculin-specific response in older people would be affected by CMV-status, phenotype or functional profile of the CMV-specific T-cell response.
In fact, cgh-1 mutants have statistically significantly more terminal branches than controls at these later stages.
We have shown that Dali regulates genes involved in neural development and function and its depletion disrupts terminal stages of neuronal differentiation, more particularly neurite outgrowth development.
We have shown also in our previous study that a significant elevation of serum antibody levels occurs in the terminal stages of Hexb−/−FcRγ+/+ mice of more than 14 weeks of age [10].
Together, this finding suggests that sup-26 and rsp-3 mutants lose more terminal dendrite branches than they form during the late-L4 stage.
Surprisingly little is known about how these terminal stages of erythropoiesis are matched by bone marrow production of more immature erythroid progenitor cells.
We collected our data before 96 hours by which time early stages of differentiation, such as early neural differentiation, may be tracked, but more terminal differentiation to heart, brain, liver, kidney has not yet taken place.
Unfortunately the answer to this question remains unclear and more work is required to determine whether the initiating oncogene is still required during the terminal stages of leukaemia evolution.
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