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The computational procedure can therefore be used, for instance, in prioritization of the most promising interactions for follow-up functional analyses or more targeted screening experiments among the exponential number of combinations.
I'm not afraid of promoting general screening, but I think that the more targeted screening procedures are under our jurisdiction.
Although most national screening programs rely solely upon age as the factor to determine eligibility (e.g., inviting only women above a certain age-threshold for screening), more targeted screening based upon a calibrated risk assessment is being considered [ 23].
While some opt for population-based screening of older people in general practice [ 6], other studies suggest that general practices benefit most from a more targeted screening approach [ 38, 39].
Furthermore, these concepts are applicable to 'developing' countries, where good outcomes could be achieved at a fraction of the costs of the Australian model, through use of community workers, mobile vans, less frequent and more targeted screening, cheaper reagents, simplified testing algorithms and generic medicines [ 28].
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Discovery of new GBS virulence factors could also contribute to more targeted prenatal screening and facilitate vaccine design [23].
For example, one could generate fluorescent reporters to readout pathway activity, which could allow for more targeted drug screening.
Among case-patients, MRSA was more frequently found in clinical samples (an unexpected finding) compared with controls, whose MRSA was found more often by targeted screening in nose, throat, and perineum.
We were surprised to find that in Geneva, young breast cancer patients with a strong family history were not diagnosed more frequently by targeted screening.
It also highlights the need for more investigation on whether pediatric AHCT survivors have higher risks of SMNs than childhood cancer survivors in general and whether the former require specific recommendations for secondary cancer screening and prevention (e.g., more frequent screening, targeted screening for specific cancer sites based on risk factors).
The yield of active pulmonary TB may be improved through more targeted application of screening practices, either based on countries of previous residence and/or risk factors for progression of LTBI to active disease[ 5, 11, 18, 35- 37].
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