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Together, the computational results further the understanding of the interactions between SMAD and other transcription factors at specific target promoters, and provide the basis for more targeted experimental verification of the co-regulatory modules.
Although more targeted experimental approaches involving gene manipulations will be required to establish the exact functions of songbird novel genes, we discuss potential implications in the context of their predicted protein domain architecture and selective tissue expression.
Our method reduces the interactions between several hundred miRNAs and several thousand mRNAs to a few miRNA-mRNA groups, thereby facilitating a more meaningful biological analysis and a more targeted experimental validation.
The simulation of animal and human tests will be performed in tandem with, and aided by, fewer yet more targeted experimental studies.
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It also means fewer mega contracts and greater use of smaller programs that can be more targeted and experimental.
Novel diagnostic techniques to identify patients earlier, together with the development of more targeted therapeutic strategies exploiting recent experimental data, may lead to improved outcome in patients with diabetic cardiomyopathy.
It is also notable that, although the chicken genome "was sequenced" by 2004 [ 4], it still requires structural annotation, more targeted sequencing to elaborate specific areas, experimental validation and sequencing of the gene-rich micro-chromosomes that currently are not included in the genome sequence at all.
Taking a more targeted approach that exploited our six species' in vivo experimental data, we looked for evidence in any genome of repeat element survival within the set of partially or fully shared CTCF-binding events.
In 1996, five years after first opening, the venue launched Phuture, a smaller room that targeted experimental sounds to offset the club's more traditional house and techno fare.
The audit argues for a more targeted approach, and Plantlife has recently launched a £200,000 project, backed by GrantScape funding, to carry out experimental conservation work on 30 Breckland sites.
The detailed information about the methods and experimental conditions used for their identification would be extremely useful for the development of more targeted prediction methodologies that would be able to take all of the above considerations into account.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com