Sentence examples for more targeted agents from inspiring English sources

However, as more targeted agents are developed their different class-specific toxicities are emerging.

The increased number and continued discovery of more targeted agents that specifically inhibit key biochemical components of the receptor signalling pathways may require modification of the standard CFU-GM assay to better predict the inhibitory nature of these TKIs.

The combination maintenance with two or more targeted agents presented an increased degree of AEs instead of improved benefits; therefore, epidermal growth factor receptor (EGFR)- and vascular endothelial growth factor receptor (VEGF -targeted agent combination was not recommended.

All oral regimens currently in the drug pipeline appear to have several advantages, compared to SOC, including much higher SVR rates (typically 90%% and higher) and fewer side effects due to the removal of interferon, and sometimes ribavirin, replacing them with more targeted agents [ 20, 21].

This result suggests that changes of gene expression in response to masitinib treatment are less numerous than those associated with gemcitabine chemotherapy, which is to be expected as masitinib is a more targeted agent.

Will someone develop more targeted chemotherapeutic agents that can more selectively kill pancreatic cancer cells while doing less damage to the rest of the body?

However, there is also a tendency for a more precisely targeted agent to have a less overall efficacy.

These methodologies will be more important as ongoing studies are now assessing more combinations of targeted agents with standard chemotherapy as well as combinations of targeted agents.

The development of newer and possibly more targeted MRI contrast agents may expand the capabilities of breast MRI.

The development of more widely effective targeted agents is therefore necessary not only to improve the treatment of advanced stage nonresectable disease but also to complement future screening capabilities in the areas of secondary and tertiary disease prevention (chemoprevention).

The basic principles involved in phase I, II, and III cancer clinical trials for both the traditional cytotoxic agents and for the more recently emerging molecularly targeted agents and cytostatic agents are discussed.