Sentence examples for more targeted agent from inspiring English sources

This result suggests that changes of gene expression in response to masitinib treatment are less numerous than those associated with gemcitabine chemotherapy, which is to be expected as masitinib is a more targeted agent.

However, as more targeted agents are developed their different class-specific toxicities are emerging.

The combination maintenance with two or more targeted agents presented an increased degree of AEs instead of improved benefits; therefore, epidermal growth factor receptor (EGFR)- and vascular endothelial growth factor receptor (VEGF -targeted agent combination was not recommended.

The increased number and continued discovery of more targeted agents that specifically inhibit key biochemical components of the receptor signalling pathways may require modification of the standard CFU-GM assay to better predict the inhibitory nature of these TKIs.

All oral regimens currently in the drug pipeline appear to have several advantages, compared to SOC, including much higher SVR rates (typically 90%% and higher) and fewer side effects due to the removal of interferon, and sometimes ribavirin, replacing them with more targeted agents [ 20, 21].

However, there is also a tendency for a more precisely targeted agent to have a less overall efficacy.

However, there is concern that the combination of chemotherapy with more than one targeted agent can be associated with reduced tolerability and no beneficial impact on efficacy [ 8, 9].

The development of newer and possibly more targeted MRI contrast agents may expand the capabilities of breast MRI.

Several investigations have applied multi-disciplinary approaches to the management of such patients demonstrating improvements in antibiotic prescription to include more targeted use of antimicrobial agents [ 35, 36].

These methodologies will be more important as ongoing studies are now assessing more combinations of targeted agents with standard chemotherapy as well as combinations of targeted agents.

The development of more widely effective targeted agents is therefore necessary not only to improve the treatment of advanced stage nonresectable disease but also to complement future screening capabilities in the areas of secondary and tertiary disease prevention (chemoprevention).