Sentence examples for more systemic effects from inspiring English sources

These include differential requirements for NMD in proliferating cells, regulation of distinct transcript classes as well as more systemic effects on alternative splicing.

To improve prognosis for these patients, future investigations for treatment with more systemic effects are warranted.

To explore innovative approaches for locally advanced pancreatic cancer, future investigations for treatment with more systemic effects and less toxicity are needed.

Clinical symptoms are well described and derive from the site of infection (purulent vaginal discharge, abdominal pain) and more systemic effects (lethargy, depression, anorexia, polyuria, polydipsia and vomiting) [ 7].

This could indicate a more systemic effect in children with symptomatic GJH.

Regular use of budesonide afforded better asthma control but had a more systemic effect than did use of budesonide as needed.

26 Regular use of budesonide afforded better exacerbation control but more systemic effect than intermittent use of budesonide given as needed or regular DSCG treatment.

Therefore, pro-inflammatory cytokines can have both a localized effect on the plaque architecture and determine occurrence of thrombotic events, and a more systemic effect, in which they affect cholesterol levels, insulin resistance and endothelial function.

In contrast, exposure to concomitantly administered saquinavir remained increased by 50 70 % and, thus, was obviously not triggered by the change for ritonavir (i.e., another more systemic effect should account for this effect).

We hypothesised that the ALN-HA composite coating is more effective on peri-implant bone while RIS-HA composite coating has more obvious systemic effects and is more effective on non-peri-implant bone.

A simple explanation of a non-linear behavioral dose response relation is that low-dose exposure produces specific and limited effects in the nervous system while more widespread, systemic effects are produced by high doses.