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Our goal is to see if this approach can produce a greater and/or more sustained response compared to our prior studies.
In the patient preference head to head comparative trials, the drugs showed similar efficacy in the short-term, in particular at 2 hours, but frovatriptan provided a more sustained response, with a lower recurrence rate, likely related to its much longer elimination half-life [6].
Importantly, we also found that an acquired chemoresistance signature could identify whether newly diagnosed gastric cancer patients would have a short or more sustained response CF therapy.
In vitro hypoxia elicits a transient constriction of pulmonary arteries within 1 2 min. This is followed by a more sustained response which, in our setup, decays over 40 minutes and, as such, protocols using hypoxia as a contractile stimuli, are time limited.
Given this latency difference, we predict that neurons receiving convergent magno- and parvocellular inputs should show a short latency response appearing with low contrast and displaying sharp orientation selectivity, followed by a more sustained response that should require higher contrast and should show less orientation selectivity.
In stark contrast, synovial fibroblasts displayed a remarkably more sustained response to TNF-α.
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Whereas O3 causes a rapid response, detected immediately after exposure and subsiding within 24 hr, urban particles cause a more progressive and sustained response, with peak increase of plasma ET-1 24 36 hr after exposure (Thomson et al. 2005; Vincent et al. 2001a).
Convergence between these pathways may lead to a synergistic feed-forward circuit, resulting in a stronger or more sustained proliferative response in breast cancer cells [ 1].
The sustained response is more likely due to tissue device interactions.
More than 96 weeks of sustained response is a predictive marker of long-term sustained response.
More than 96 weeks of sustained response is a predictive marker for long-term sustained response.
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