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Technology analysts talk of something called the "hype cycle", where feverish excitement building around a product is followed by an immediate slump once it has been launched, which in turn is followed by a more sustained increase or decrease in interest based on how well it actually works.
There then appeared to be a steady mass gain from first puff, followed by a repeated pattern of response per cigarette puff: a rapid initial increase in mass then a slower but more sustained increase in mass, concluding in a slight decease in mass (outlined in Figure 3A).
In bone marrow, we observed a bi-modal pattern with a transient peak on Day 5, and a more sustained increase from day 45 onwards.
When Rab4b expression was decreased with specific siRNAs by two fold, an extent similar to its decrease in obese diabetic subjects, we observed a small increase (25%) in basal deoxyglucose uptake and a more sustained increase (40%) in presence of submaximal and maximal insulin concentrations.
The larger and more sustained increase in miR-34a levels detected in CA1 was unexpected because the CA1 subfield is less damaged in the model.
IFN-α stimulates a rapid peaked induction of ISGs, whereas IFNL3 induces a slower, but more sustained increase in gene expression.
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For example, in native grassland pasture, rooting was initially associated with declines in plant species richness, while in sown pastures, rooting was associated with more sustained increases in plant species richness.
Lipopolysaccharide-injection led to a sharp rise in prostaglandin E2 at PIH 8, while substance P, bradykinin and matrix metalloproteinase activity showed more sustained increases at PIH 8 and 24.
Induction of inflammation led to a sharp rise in prostaglandin E2 at PIH 8, while substance P, bradykinin and MMP activity showed more sustained increases at PIH 8 and 24.
"However, this is offset to some degree by the more modest but sustained increase in the direct sentenced population".
PPIs achieve a more rapid and sustained increase in gastric pH and are not associated with the rapid tachyphylaxis seen with H2RAs.
More suggestions(15)
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more gradual increase
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more sustained commitment
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com