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Gene therapy can provide more sustained expression of osteogenic factors such as bone morphogenetic protein-2 (BMP-2).
This could result in a more sustained expression of the Ag in vaccination experiments with integrative vector particles.
This indicated that there might be the need for more sustained expression of FTa1, particularly in younger plants in LD.
The MS-275-pulse caused a slight decrease of the neuroectodermal marker Pax6 expression, accompanied by an earlier, and more sustained expression of Nestin (Fig. 3D).
For instance, short-term expression may suffice to induce vasculogenenesis for the treatment of myocardial infarction (MI), whereas more sustained expression may be required to achieve left ventricular remodelling in HF.
Therefore, injury-induced production of ROS by retinal neurons leads to stabilization of Lif mRNA that may result in a more sustained expression when LIF signaling is necessary to preserve neurons.
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A CBF2 knockout mutant, cbf2, had a higher capacity to tolerate freezing than wild-type ones which was correlated with stronger and more-sustained expressions of CBF1 and CBF3 in the mutant.
IFN-α stimulates a rapid peaked induction of ISGs, whereas IFNL3 induces a slower, but more sustained increase in gene expression.
To silence gene expression in a more sustained way, targeted DNA methylation has been achieved by fusing a DNA methyltransferase to a DNA binding domain like zinc-fingers (Smith et al, 2008).
More indirectly, Kit signaling contributes to the sustained expression of Stat5 protein which can then be activated by Epo [38].
In our study, the higher p53 expression observed in Nrf2 KO mice after UVB exposure could be an indicator of more sustained DNA damage in need of repair.
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