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Exact(7)
The 8-OHdG biomarker was used because the half-life of reactive oxygen species is extremely short (milliseconds) and therefore common measurements of OS status are based on the detection of their more sustained effects on other molecules.
5 7 It is argued that changing the environment may be required to produce broader and more sustained effects, but this is mostly based on evidence from cross-sectional observational studies.
However, since the effect was not generated until the last four weeks of the study a longer period than eight weeks might be needed to generate more sustained effects when both activities are used in combination.
Therefore a 2 year study period was used in the cohort study to allow for the more sustained effects to be evident, and to assess if different cohorts of franchise members are experiencing similar trajectories of revenue and case load growth.
It has been consistently demonstrated that early life exposure may have greater and more sustained effects on the gut microbiome than exposures later on in adult life [ 30, 33, 34, 45].
Much more fundamental for the health of the exchequer, not to mention the wealth of the nation, are both the immediate and more sustained effects upon output which would come about with a British decision to leave.
Similar(53)
The use of gene transfer to deliver an expression cassette to photoreceptors and RPE cells that produces a similar inhibitory molecule may be a less invasive strategy as it could produce a more sustained effect.
However, it showed a more favorable sustained effect, as shown by a lower rate of migraine recurrence.
While only a single experiment, this provocative result suggested that growth-stimulatory fibroblasts identified in vitro might be capable of exerting both transient and more sustained tumorigenic effects on adjacent cancer cells in vivo.
This masked cluster of molecules was expected to produce more sustained antitumour effects with the prospect of inducing activities similar or superior to that of classical combinations involving a reversible EGFR inhibitor+a cytotoxic drug.
The results of our study support the hypothesis that aprepitant is effective in decreasing the incidence of delayed nausea with a more sustained antiemetic effect.
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