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According to our analysis of individual studies F is as effective as other triptans in the immediate treatment of menstrual migraine attacks, but exhibits a more sustained effect.
However, the presence of Trp complexed by the HA supra-structure assures and enlarges the in vitro biostimulant action of Trp by delaying fast Trp degradation, thus promoting a more sustained effect [25].
Decreasing the expression levels of Rab4b mRNA by 60% yields to a small increase in basal glucose uptake and a more sustained effect at a physiological and maximal concentration of insulin.
Sexual status had a more sustained effect on fitness however - after 225 generations sexual populations consistently achieved greater fitness (P < 0.03), regardless of mutation rate.
Vildagliptin caused a significantly smaller reduction in FPG than rosiglitazone (Table 4), suggesting a more sustained effect throughout the day (Rosenstock et al. 2007b).
The rise per week was statistically significantly smaller with saxagliptin versus glipizide (−0.002% difference, 95% CI, −0.0046% to −0.0001%; P = 0.04) indicating a more sustained effect on glycemic control beyond week 24.
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Much more fundamental for the health of the exchequer, not to mention the wealth of the nation, are both the immediate and more sustained effects upon output which would come about with a British decision to leave.
Finally, the next logical step for the stealth intervention approach is to harness the motivational appeal of existing and emerging social and ideological movements, to achieve greater and more sustained effects on behavior.
It has been consistently demonstrated that early life exposure may have greater and more sustained effects on the gut microbiome than exposures later on in adult life [ 30, 33, 34, 45].
That suggests that melatonin is also secreted directly into the CSF, where it may have direct and perhaps more-sustained effects on target areas of the central nervous system.
In addition, the most significant result of our studies was a more sustained relieving effect on migraine symptoms with frovatriptan, with lower headache recurrence rates over the 48 h; these results are in line with previous reports comparing frovatriptan with placebo [7 9] or sumatriptan [10].
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