Sentence examples for more sustained activation from inspiring English sources

This modification results in loss of its lipid phosphatase activity and yields a more sustained activation of signaling events downstream of PI3K.

DBM contains the collagen necessary to activate PRP, but in amounts small enough to create a slower, more sustained activation and release of PRP growth factors than the thrombin activation [ 37].

It is possible that DMR0 hypomethylation is associated with a more sustained activation of IGF2 in tumour cells as a result of alternative high level chromatin conformation promoted by tumour-specific activators.

These differences could reflect strong but brief activation in response to the CS+ for conditionable participants, as opposed to weaker but more sustained activation for unconditionable participants.

On the other hand, longer signal duration at the level of the receptor leads to a mitogenic response of insulin [ 56- 59] suggesting that mitogenic signaling is mediated by a more sustained activation of the IR.

In adult mice, MPTP administration increased striatal expression of the astrocyte-specific marker, glial fibrillary acidic protein (GFAP) in both sexes, but a time-course study over 21 days revealed a more sustained activation in females (Ciesielska et al., 2009).

We detected a more enduring and sustained activation of P38 in those cells stimulated by EPO than by SCF, suggesting a physiologic role for P38 in erythropoiesis (Fig. 1a and Supplementary Fig. 1b).

Since HRG induces stronger and more sustained PI3K activation (as measured by Akt activation) compared with EGF, we hypothesized that PI3K might determine the ability of MCF-7 cells to undergo phenotypic changes.

Similarly, it is possible that transient ligand exposure results in homologous receptor desensitization of both CXCR4 and CXCR7, while those receptors are more resilient to more sustained receptor activation.

Indeed, transcriptional data indicate a more sustained UPR activation in transformed cells as compared with normal cells, as several UPR-related genes and relative targets are more actively expressed in these cells.

In contrast, in order for gametogenesis to be completed sustained activation of PI-PLC for a more extended period, resulting in increasing IP3 levels, is required.