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Determining the nature of lung deficiencies is essential to provide the more suitable therapeutic strategy.
These predictions were validated with in vitro cytotoxicity experiments, demonstrating that mutant Tf-CRM107 conjugates is indeed a more suitable therapeutic agent.
This suggests that if TOR or Akt were to be independently targeted, AKT might be a more suitable therapeutic target.
This approach allows for more suitable therapeutic strategies based on clinical information of individuals.
Both the hydrophobic pocket and the Cys133 have been shown to be the effective target sites for TLR4 signalling antagonists and MD-2 has been proposed to be a more suitable therapeutic target for pharmacological intervention than TLR4 (Mancek-Keber et al., 2009).
Roflumilast, which has now been approved for use as a therapy in COPD (Huang and Mancini, 2006) does not discriminate HARBS from LARBS and, given its higher tolerability in vivo compared with rolipram, may provide a more suitable therapeutic agent for treating SCI.
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For these reasons, Sk-34 cells can be purified more simply and in much larger quantities, and are more suitable for therapeutic use, as they can be obtained within 3 hours of muscle sampling.
Therefore, a transient introduction of the construct can lead to a persistent modulation of gene expression without any genomic damage being introduced, hence making epigenetic editing safer and more suitable for therapeutic use.
The polymer- and lipid-based nanovehicles are more suitable for delivering therapeutic genes, owing to their high reproducibility, ease of manufacture and functional modification, and safety (they are not carcinogenic) [ 3].
Taken together, using an in vitro model, we can replace and reduce the number of animals necessary to test combinations of therapeutic agents for the potential repair of SCI and have identified more specific and suitable therapeutic targets, including HARBS, Epac and co-inhibition of PDE4 and Rho/ROCK for the treatment of SCI.
Additionally, FBS coatings may also provide a potential approach to reduce the IC50 values of nZnO against cancer cells from their current millimolar range to more suitable ranges appropriate for therapeutic applications.
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