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In the dermal-epidermal membrane systems, a more suitable microenvironment for the SSCs differentiation was promoted by the interactions and the mutual interplay with keratinocytes.
This gel can provide a more suitable microenvironment by using the amphiphilic triblock copolymer (mPEG550PLGA1405) consisting of methoxy poly ethylene glycol) (mPEG), poly(lactic-co-glycolic acid) (PLGA).
Many authors demonstrated ECM-based scaffold efficacy in creating a more suitable microenvironment to sustain cellular adhesion.
Therefore, blocking the pro-inflammatory cytokine induced cartilage degeneration and inflammatory cascades might create a more suitable microenvironment for the chondrogenesis of MSC-like progenitors.
The aim of the present investigation was to evaluate whether IL-1β stimulated MSCs (either alone or in a co-culture model of OA with primary chondrocytes) pre-treated with curcumin may impede the adverse effects of this pro-inflammatory cytokine and create a more suitable microenvironment for the chondrogenic differentiation of cartilage resident progenitor cells.
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Compared with conventional gelatin gel (Gel-G) scaffold, the Gel-MCG provides more suitable microenvironments for EPOCs' attachment, spreading, and proliferation, and then which leads to enhanced endothelial differentiation and vascularization as demonstrated by higher expressions of endothelial markers.
This capability probably renders the neoplastic microenvironment more suitable for the survival and expansion of the breast carcinoma cells.
In addition, chemokines make the tumor microenvironment more suitable for tumor growth by induction of leucocytes migration and activation of inflammatory responses [ 14].
The consequential transformation of microenvironment is more suitable for cancer survival.
The expression of EBER1 and latent genes in XUNE2-P1 was higher than that in SUNE2 cells, likely because the in vivo microenvironment provides more suitable conditions for promoting retention of the EBV genome.
Further covalent incorporation of various amines including single amine group, multi-amine groups of diethylenediamine (DETA), and poly-amine groups of polyethylenimine (PEI) to the network gave rise to task-specific modification of the microenvironments to make them more suitable for CO2 capture.
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