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"The next stage would be to repeat the study in primates, a more suitable animal model where HIV infection induces disease, in order to further demonstrate elimination of HIV-1 DNA in latently infected T cells and other sanctuary sites for HIV-1, including brain cells," said co-author of the study Dr. Khalili in a statement.
Based on observational and dimensional features of the two animal models reported in this study, our data indicated that the main dimensional parameters of the sheep model would make it a more suitable animal proxy, supporting other reports advocating the use of the sheep model in meniscal research related to physical dimensions.
This suggests that it may be prudent to create more suitable animal models besides mouse so as to verify MSC-mediated immunosuppression in vivo.
Hence a more suitable animal model is needed to more closely mimic the resulting cognitive decline and memory loss in humans in order to investigate the effects of neuroinflammation on neurodegeneration.
Therefore, the next step in this research is to find a more suitable animal in which to study the role of this protein, which may inform efforts to develop treatments for Joubert syndrome.
Recent studies by Schmelz and colleagues have shown that C-MiHi units are also present in the skin of the pig, which they have claimed may be a more suitable animal model for human nociceptors (Obreja & Schmelz, 2010).
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Advantages in animal husbandry, large litter size and short generation interval of pigs make them more suitable as animal models over primate models, although the phylogenetic relationship of pigs to humans is more distant than that of primates to humans.
The rabbit model provides a more suitable small animal model for the assessment of cartilage repair as they have larger joints and are a good size for easy surgical procedures and specimen handling with a cartilage thickness of 0.25 mm–0.75 mm (Table 1) (Fig. 1).
We suggest therefore, that C57BL/6 mice are a more suitable host animal model for studies that require GFP-labeled stem cells tracking.
To investigate the connection between neuroinflammation and AD and to test potential anti-inflammatory drugs, a more suitable "neuroinflammatory" animal model is needed, showing the level of neuroinflammation comparable to the human conditions.
This evolutionary relationship has made this primate as a more suitable experimental animal model than rodents, dogs, and pigs and may lead to its widespread use for the translational studies for drug testing [ 1].
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