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The aim should be that 10% or fewer controls will have two or more such variants.
Many more such variants are likely to be identified in the coming years.
We have experimentally identified two splice variants of the first characterized P450 gene pc-1 (CYP63A1) from P. chrysosporium [ 12] and predicted more such variants based on the in silico analysis.
There is clear evidence for the involvement of several large, rare genomic copy number variants in schizophrenia, and it is likely that many more such variants will be implicated in the disorder over the coming years.
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It is expected that hundreds more such genetic variants may be discovered (Flint and Kendler, 2014), with each contributing relatively small effects to the overall risk of depression.
More likely, such variants represent very rare or population-specific variants.
With the new genotyping arrays that focus on low-frequency and rare variants, studying populations of diverse ancestry will become even more important as such variants are more likely to be ancestry-specific.
Such variants are more difficult to identify by endoscopy and initially reported only in Japan.
Such variants are more likely to be encountered in captive snakes or wild snakes from outside eastern North America (since most characterized strains upon which the assays were designed originated in the eastern U.S).
Hence, between-population allele frequency differences may be more extreme in genome regions harboring such variants.
As more microdeletions are reported and technologies for the detection of these and other putatively causal variants become more accessible, interest in searching for such variants will increase.
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