Identifying the synaptic vesicle as the principle organelle of APP trafficking in the synapse, however, raises the hope of developing more subtle treatments that selectively modulate protein processing and release.
Constantly praising one child and criticizing another is a more obvious form of differential treatment, but what about more subtle alterations in treatment and expectations?
These are deemed more sensitive to subtle treatment benefits, as they contain more varied and disease specific dimensions [ 7].
Previous studies have documented important changes in patients' ability to function following cancer treatment but the goal of survivorship research has expanded to include understanding the more subtle effects of treatment [ 25].
Whether this method is also useful for analyzing more subtle effects of neuroprotective treatment (partial protection) remains to be established, by studying mice with small dopaminergic lesions.
The low number of subjects is not sufficient to demonstrate whether other more subtle effects (e.g., treatment effects), besides differentiating between disease outcomes, can be demonstrated from application of the SUVfixed volume and mSUVthreshold metrics.
2 4–6 Clinician anxieties about treatment toxicity, side effects and burden may be an important constraining influence on the intensity of cancer treatment offered to older people, 7 8 but other more subtle factors may also influence treatment decisions.
In this study, I replicate and extend the findings of a randomized field experiment designed to study the impact of more subtle, implicit social pressure treatments on voting.
The effects of NB30 and PTC124 treatment were more subtle, resulting in a 1.8-fold and a 1.7-fold increase in full-length protein, respectively (Fig 2B, Table 1).
