Sentence examples for more subtle sequence from inspiring English sources

Herein, we present analyses suggesting that more subtle sequence selection pressure, including propensity for secondary structure, the hydrophobic core organization and charge distribution are imposed on the Raf RBD sequence.

In addition to digesting naked DNA, the MNase is known to cleave AT/TA dinucleotide motifs as well as showing other, more subtle, sequence specificity (Horz and Altenburger, 1981).

This section also investigates more subtle sequence features as compartment determinants by training classifiers that are evaluated (on held-out proteins for which compartments are known) and then used to characterize proteins with no presently known nuclear compartment.

Although N =  2 position-independent models capture global nucleosome occupancy trends, they disregard more subtle sequence signals such as 10 11 bp periodic dinucleotide distributions which are thought to facilitate bending of nucleosomal DNA into the superhelical shape [ 1, 53].

The common theme with all genome editing approaches is the use of a site-specific nuclease that cleaves the genome at a defined site, thus triggering a repair event that can be guided to yield outcomes ranging from complete gene deletion to more subtle sequence alterations [ 5].

Change in gene function might not necessarily require large changes in evolutionary rate or amino acid sequence however, with more subtle changes in sequence or regulation also able to bring about functional change.

Although many base modifications, such as 6mA, 4mC, 5hmC and 8-oxo-guanine, are readily detectable in SMRT sequencing [ 16, 17, 20, 21], the kinetic signature of 5mC is more subtle, requiring high sequencing fold coverage to make out the small effect on polymerase speed.

These methods include generalized profiles and Hidden Markov Models (HMMs), which can detect more subtle homologies than pairwise sequence alignments (Park et al., 1998).

The design of the hybridization experiments (Fig. 1) enables discrimination between the strong influence of defect position [ 7, 9, 10] and the more subtle defect-type and sequence related factors.

In the cases of GPCR and enzymes, almost no structure is found by the sequence kernels, which, as alluded to above, was expected and suggests that more subtle comparison of the sequences would be required to exploit the information they contain.

Similarly effective were more subtle experiments that modified the sequences of two genes, orc1 and kelch13, which have putative roles in gene silencing and emerging resistance to artemisinin, respectively.