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This is a gross computation that can be divided in more subtle phenomena.
As it can be difficult to probe some of the more subtle phenomena by experiment, numerical simulations can be illuminating.
Although dichotomizing variables may obscure more subtle phenomena in the ECEC selection process such as non-linear relationships, it facilitates comparisons across studies and makes the results more useful for policy makers who often design policies for families above or below a certain cutoff (e.g., poverty status).
A more recent study of this model has shown that down-modulation is not always the case, in that late-stage tumors (including invasive carcinomas) in the current backcross generations typically have apoptotic rates similar to those of angiogenic islets, suggesting a more subtle phenomena at play in expansive tumor growth (ref [16]).
We discuss de novo preplay below in more detail, in brief though: Because de novo preplay is thought to depend upon preconfigured cell assemblies as opposed to networks shaped by direct experience, we believe it to be a more subtle phenomena than replay of a familiar environment.
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Uncertainty, though, is a more subtle phenomenon.
However, if you ask about gradations of the "yes" (or gradations of agreeing), then if there is a more subtle phenomenon going on you have a better chance of catching it.
And a recent research study indicated that racism has only become a "more subtle" phenomenon in our nation.
Moreover, the difference in data and shuffle distributions are also small for Cued Arm preplay in Rest 2. As a comparison, for previous results in de novo preplay, (Dragoi and Tonegawa, 2011, Nature), which the authors mention might be a relatively more subtle phenomenon, the preplay effect was stronger based on the distribution based analysis.
The development of TV costume drama in the 1950s and 1960s created a more subtle version of the same phenomenon: an imaginary "Dickensland" in which fog always swirled and bonnets always bobbed along murkily lit streets.
Such gross examples are relatively easy to identify, and such patients can be removed from analysis; what we do not know is whether more subtle examples of the same phenomenon are contaminating the remaining data.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com