Sentence examples for more subtle molecular from inspiring English sources

More subtle molecular clock issues arise from the fact that mutations can result in variable amino acid replacement rates in proteins, especially among primates.

These results suggest that more subtle molecular differences distinguish infectious from non-infectious PrP.

This may be due to fewer and more subtle molecular differences between subsets of ER-negative cancers or to a larger number of subsets that exist among these tumours, and therefore their delineation will require much larger sample sizes than currently available.

It is likely that only a subset of these structural and stereoisomers would lead to stable base-pairing systems, and we presently have no guiding algorithm to predict the location or population density of base-pairing systems in molecular formula or structure space, which undoubtedly depends on more subtle questions of molecular geometry and stereoelectronics.

The potential for more subtle toxicities with molecular-targeted agents will, however, require long-term monitoring.

However, further comparison of the list with genes up-regulated in the Frzb-/ mice with a user-compiled list of WNT target genes (see Additional file 1), did reveal consistent up-regulation of such targets indicating that more subtle changes at the molecular level are present (Yates corrected Chi-square test P < 0.0001).

One question that arises immediately is how to distinguish "substantial" and more "subtle" functional changes at the molecular level?

Our comparative analysis of results obtained in parallel that incorporated molecular biology and a RIDT led to a more subtle assessment.

However, to detect more subtle differences between land plant proteomes, more robust methods using protein structure and molecular dynamic simulations [ 59] may be needed to resolve more subtle protein adaptations to thermal stress.

For cocaine hydrochloride and morphine, it was the ability for the drug to be injected leading to rapid reinforcement whilst for crack cocaine and methamphetamine subtle molecular alteration allowed the drug to be smoked leading to a more rapid onset of action with a shorter, more intense high.

These molecular changes also occurred before overt clinical manifestations, suggesting that the markers are sensitive to more subtle loss of motor neurons.