That more subtle modifications of the gut microbiota might be relevant is suggested by a report of an association between childhood exposure to antibiotics and the development of IBD in later childhood [ 8].
In particular, chimeric pestiviruses with substitution of the entire E2 protein have been described [ 15- 17] but also mutants with more subtle modifications, such as the modification of the important TAV-epitope [ 18] within the CSFV-E2 protein [ 19, 20] are promising marker vaccine candidates.
A more subtle maladaptive modification would be to overly rely on "safety signals" to indicate that an aversive stimulus will not occur in a situation (Campbell-Sills & Barlow, 2007).
Conceptually the focus is moving from a quantitative measure of any given biomolecule(s) but to compositional profiles [ 28, 29] and the more subtle post translational modification of proteins – the proteoform - that are markers of a disease process [ 25].
These remarks suggest that more subtle investigations and modifications of structures on X, and the concept of distance of Hausdorff defined by (1.2), and the concepts of contractions of Banach and Nadler defined by (1.1) and (1.3) respectively are necessary.
Color and consistence are evident at a glance, while other features such as shrinkage and surface modifications are more subtle.
In the future, it would be interesting to investigate more subtle changes in the different layers such as modification in the expression of neurotransmitters or neuroaxonal damages.
High sequence conservation of sites directly involved in oxygen binding indicates that functional modifications of octopod haemocyanin rather occur via more subtle mechanisms, as observed in this study.
Long-time readers may know that I'm no great fan of those sorts of manufacturer-mandated modifications, but HTC has been consciously dialing down the once-overwrought Sense experience into something more subtle and fluid.
