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More subtle functional and physical impairments may also be evident.
One question that arises immediately is how to distinguish "substantial" and more "subtle" functional changes at the molecular level?
Progressive iterative signature algorithm (PISA) is another interesting approach, where larger functional modules are iteratively identified and removed to find more subtle functional modules (Kloster et al., 2005).
Because prenatal Hg exposure at high levels induces widespread damage to the developing brain, we assumed that more subtle low-level exposures should trigger more subtle functional disturbances.
Instead, structural, functional and biodiversity indicators are required to capture critically important yet more subtle functional changes across different spatial and temporal scales (Laliberté and Tylianakis 2010).
Moreover, further electrophysiological functional analysis of the synaptic contacts could reveal more subtle functional deficits (Cruikshank et al. 2010; Kloc and Maffei 2014).
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Yet, as the sample for the CBT treatment group was sufficient to detect a predictive potential of functional MRI [7], it is possible that if structural effects exist, they might be more subtle than functional ones.
The investigation of the possibility of more subtle or functional effects on the transcription of genes, for example, requires the use of more sensitive methods, including gene and protein expression studies.
Thus, there is no evidence to suggest that cilial morphology or transport is grossly disrupted in hitchhiker mutants, although more subtle structural or functional defects would not have been detected.
It could also be the case, that the macroscopically normal volume of a certain brain area might mask more subtle histological alterations or functional anomalies not related to structural change.
We hypothesized that the application of correlational analyses to resting-state fMRI data in a single study can enable the characterization of task-independent patterns of functional connectivity with more subtle regional differentiations.
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