Although high-dose MeHg poisoning has been shown to cause developmental disorders, evidence that more subtle low-level developmental exposure contributes to these disorders is limited.
Rather than a simple dichotomous transition from absence to presence of HPA axis dysregulation when one compares child versus adult manifestations of depression, the consideration of longitudinal data across developmental periods suggests more subtle, progressive changes in HPA axis functioning.
However, the majority of children exposed to dexamethasone in the neonatal period do not develop cerebral palsy or global developmental delay, and other more subtle effects of early life glucocorticoid exposure may go unnoticed.
Damage caused by these compounds may, in the long term, lead to drastic effects such as decreased reproduction, or perhaps more subtle effects, such as a disturbance to the developmental system resulting in behavioral effects (e.g., learning disorders).
The developmental rate response to oxygen is more subtle, yet causes more problems, across the range we tested than is seen with a moderate change in temperature.
Achieving this understanding necessitated moving away from β3-KO animals, which are often criticised for sustaining angiogenesis through developmental upregulation of VEGFR2, to a more subtle, albeit global, alteration in β3-integrin expression – β3 heterozygosity.
The more subtle effects of conventional LIMK1 knockout may be due to developmental compensation by other pathways.
A lack of giant multinuclear neurons and large, ballooned glial cells typical of focal cortical dysplasia indicated that the observed developmental changes in neocortex and archicortex reflect a more subtle cortical malformation, classified usually as focal cortical microdysgenesis.
Nonetheless, future work with depressed young people will gain power from the collection of larger samples sizes, which may allow for the detection of more subtle changes across various indices of basal and/or diurnal variation during this developmental period.
Executive function tasks appear to be more significantly affected in the early severe hypoglycemia subgroup, suggesting that there may be subtle developmental changes in the frontal cortex.
