Sentence examples for more subtle defects from inspiring English sources

In incrosses of atp1a3a tpl10 heterozygotes we did not observe embryos with severely dilated (or otherwise morphologically defective) brain ventricles, but we have not assessed them for more subtle defects (Additional file 7: Figure S5A).

Note that patients without obvious hiatus hernia may still have increased compliance secondary to more subtle defects at the EGJ not readily evident using current radiographic or endoscopic methods of evaluation.

Analysis of the biochemical impacts of PTPN11 mutations first identified both loss-of-function and gain-of-function mutations, as well as more subtle defects, highlighting the major pathophysiological consequences of SHP2 dysregulation.

Recognizable chromosomal variants account for 13% of all CHD patients although high-resolution technologies may uncover more subtle defects [3].

More subtle defects in nephron number have been associated with the development of adult-onset essential hypertension and chronic renal failure [1], [2], [3], [4], [5].

Specifically, an ssa1Δ mutant, in an otherwise wild-type background for the other Ssa-encoding genes, is more affected in mat formation than an ssa2Δ mutant that has more subtle defects in this process [39].

The design of the hybridization experiments (Fig. 1) enables discrimination between the strong influence of defect position [ 7, 9, 10] and the more subtle defect-type and sequence related factors.

However, histological examination of intestines did not indicate an effect on overall tissue integrity or differences in proliferative responses of control and shBrd4 groups at this dose of doxorubicin, possibly pointing to a more subtle defect.

Nevertheless, additional experiments are required for the formal exclusion of more subtle axonal defects, such as changes in axonal transport, which might precede intramyelinic oedema.

Next, we constructed a ybp2Δmad2Δ double mutant in our background (YPH499) to assess the double mutant for a more subtle synthetic fitness defect.

Thus, there is no evidence to suggest that cilial morphology or transport is grossly disrupted in hitchhiker mutants, although more subtle structural or functional defects would not have been detected.