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Secondly, the study may have been underpowered to detect more subtle clinical differences between patient groups.
More subtle clinical typing (i.e., single-domain aMCI and multiple-domain aMCI) will be necessary to validate this finding.
However, a limitation of this methodology is that the expected improvement over this period is rather large and it says nothing about responsiveness for more subtle clinical changes.
It is possible that more subtle clinical findings like ANA or altered proteomic and gene expression profiles are present in genetically-related individuals with and without autoimmune disease [ 29, 30].
Although cerebellar lesions may cause conspicuous neurologic signs, e.g., ataxia and loss of balance, cerebral lesions may cause more subtle clinical signs, e.g., altered mental attitude, which were not noticed under these experimental conditions (36 ).
Despite the present study's prospective design and relatively large sample size, we cannot exclude the possibility that we are still underpowered to identify more subtle clinical and demographic predictors of decline in percentage predicted FVC.
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Other clinical signs of tendon pathology may be much more subtle and require careful clinical examination.
The explanations offered centred on more subtle organisational or indirect clinical benefits.
The cases of severe hepatocellular injury caused by SOS were far more subtle, as the typical clinical manifestations of SOS (painful hepatomegaly, weight gain, ascites, jaundice) occurred in the first 10 days after transplant 19, but the initial rises in serum AST were days to weeks later.
In healthy subjects, this task is even more difficult, as abnormalities are more subtle and of less obvious clinical consequence, at least in the short-term.
The small number of patients could make our study underpowered to reveal more subtle findings, such as correlation between clinical features and functional connectivity, although our cohort was sufficient to disclose strong statistical significance.
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