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49 The small sample may have precluded identification of more subtle brain alterations in HIV seroconversion and of additional host factors associated with increased risk.
A significant reduction in the cross-sectional area of the C 2-segment of the corpus callosum in the non-abusing patients in comparison with the patients with previous cannabis abuse could be observed, suggesting more subtle brain abnormalities in the group without previous substance abuse [ 32].
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The prevalence and type of brain lesion in asymptomatic patients or in those with more-subtle brain dysfunction was not analyzed.
This loss of handedness, the researchers report today in Biology Letters, may be a sign of other, more subtle developmental brain dysfunctions that might hurt the ability of this fish, and other marine species that could be similarly affected by CO2, to survive in a high-carbon future. .
This highlights the relative tolerance of the brain to foreign tissues yet strengthens the importance of recognizing and understanding the more subtle immune-brain interaction that revolves around innate immune response and elaboration of proinflammatory cytokines.
It has been possible to investigate the more subtle changes in brain structures in vivo only relatively recently.
However, it would be worthwhile confirming the findings in a larger cohort which would also have the power to detect more subtle differences between brain regions.
It has also been speculated that the constant presence of HIV and the associated immunoactivation and inflammation in CSF is linked to this more subtle form of brain injury.
Visual perceptive dysfunction in ex-preterm children without major sequelae of prematurity depends on more subtle changes in the brain microstructure, including CC. Role of interhemispheric connections in visual perception might be more complex than previously anticipated.
The increasing problem of diffuse brain injury [ 28] raises in our opinion the need for more subtle models of inflammation triggered brain injury.
Another improvement could see more electrodes added to the brain chip, so more subtle signals can be detected and passed on to the patient's muscles.
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