Given that it is unlikely that the more subtle defects associated with neurodevelopment (such as incomplete synapse refinement for example) would disrupt the relatively gross changes associated with metamorphosis (such as loss of the tail, emergence of limb buds and formation of lungs), disorders in nervous system development could go undetected.
Imposed on the dramatic covalent recoupled pair bond variations are more subtle variations associated with rearrangements of the bonding pairs caused by the strength of the recoupled pair bond dyad (ala SF3).
The stronger of these two gradients reflected the continuous variation in canopy cover and gap volume, while a second, more subtle gradient was associated with the array of possible vertical and horizontal spatial configurations that might define any one measure of canopy cover.
However, this finding does not eliminate the possibility that changes in CSF cystatin C levels correlate with more subtle biochemical changes associated with disease progression, as these may not be accurately reflected by overt functional measures of clinical disease status [9], [11].
Improving upon cataract severity measurement using computerized assessment methods could provide a means for cataract researchers to explore more subtle risk factors associated with disease progression.
Petal-specific downregulation in the ABP would also prevent more subtle pleiotropic consequences recently associated with floral anthocyanin polymorphisms such as changes in floral scent [52] and decreased leaf glucosinolate induction [6].
44 As geneticists study the action of these genes and the mutations in different regions, more subtle phenotypes are being associated with each [e.g., 15 16].
In order to understand if more subtle functional changes were associated with CMV serostatus, we finally analyzed the distribution of 31 non-overlapping Boolean subsets defined by the 5 activation markers (Lachmann et al., 2012; Roederer et al., 2011).
It has then be demonstrated that variants of the WNK1 gene not only cause this severe Mendelian form of hypertension but that more subtle variants are also associated with blood pressure variation in a severely hypertensive [99] and in the general population [100].
In Lyme disease (lower Bb densities), changes in microvessel permeability may be more subtle and may directly associate with the local adhesion and penetration of Bb across microvessel walls.
Long-term, low-level exposure has been associated with more subtle symptoms of erethism, including fatigue, irritability, loss of memory, vivid dreams and depression.
