Constantly praising one child and criticizing another is a more obvious form of differential treatment, but what about more subtle alterations in treatment and expectations?
Candidate precursor lesions include dysplasia [13], hyperplasia [14], and more subtle alterations involving cellular or nuclear "atypia" [15], [16].
More subtle alterations in stem cell proliferation can affect overall size of a seed-producing inflorescence structures, such as a maize cob, the size of a fruit, or the number of petals in a horticultural flower.
As discussed above, complete deficit of C2 or C4 appears to cause SLE, and more subtle alterations in the classical pathway may also cause some tendency toward autoimmunity.
Alternatively, more subtle alterations in translational control of selective mRNA subsets could be fundamental to the involvement of translation factors in tumorigenesis.
There is a risk that more subtle alterations in several substances simultaneously are not detected using classical statistical methods [ 27, 28].
Mouse models of AD do not show presence of fragmented microglia, although a recent study demonstrates other, more subtle alterations in microglial morphology amounting to cells being less ramified and possessing fewer branches and fine processes [ 154].
Thus, we reasoned that assessing the time-course expression of oligodendrocyte-specific genes by qPCR could highlight more subtle alterations between WT and Twi and, consequently, between treated Twi mice and UT littermates.
We suggest that neonatal exposure to 500 μg BPA (a dose higher than the LOAEL) provoked irreversible alterations in the hypothalamic pituitary gonadal axis that led to anovulation and infertility, and that 50 μg BPA (a dose lower than the LOAEL) provoked more subtle alterations at the hypothalamic level that could lead to subfertility.
The general explanations offered include disruption of water structure in the vicinity of the active site formation of higher intrinsic activity resulting in as high as tenfold increase, or presence of high concentrations of miscible organic solvents may induce gross changes in substrate specificity and/or more subtle alterations in chiral selectivity [ 39, 40].
