Sentence examples for more substrate binding from inspiring English sources

The TMDs contain one or more substrate binding sites.

Dcp2 catalysis is promoted by the closing of the bi-lobed Dcp2 structure to create a more active enzyme and more stable substrate binding (Deshmukh et al. 2008; She et al. 2008; Floor et al. 2010).

The overall structural similarity is low, with APH2 having a more elaborate substrate binding region.

Selection may be towards more favorable substrate binding, better interactions with accessory redox proteins, such as cellobiose dehydrogenase enzymes, or perhaps both.

A reasonable interpretation of this result is that the TMAO stabilizes a conformational ensemble that more closely approximates that of the wild-type enzyme, providing a more substrate-accommodating binding site than the structure with an unfolded LD.

Remarkably, the formation of an intramolecular disulfide bond of Cys46-Cys55 in F46C/M55C Mb improves the protein stability and regulates the heme site to be more favorable for substrate binding, resulting in enhanced peroxidase activity.

The most noticeable movements occur in Phe89, Phe137 and Gly138 upon accommodation of D-Tyr3AA making the active site more compatible for substrate binding.

In spite of the structural plasticity of CYP3A4, we have been able to use MD simulations to identify plausible productive and nonproductive binding modes for one or more substrate molecules in the substrate-binding pocket of the enzyme.

This structure allowed a more precise analysis of the active site, generating a more reliable model for substrate binding.

The results demonstrate that WbnH structure is more close to the substrate binding PimA than apo-PimA (DALI Z-score of 28.3 versus 26.4) (Figs. 1D and S2).

The search for the function-determining amino acids continues and after decades of intensive research we still do not know more than that the substrate binding residues must be directly responsible for the mono- and/or diphenolase activity.