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However, this is not an exhaustive guide for clinical care and, as pointed out by the authors, does not obviate consultation of a more substantial reference or an expert in the management of a specific disease.
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Because a number of the nonprogressors would probably ultimately develop type 1 diabetes, and thus were not metabolically normal, differences between progressors and a normal reference group could be even more substantial.
Two or more substantial placements in schools equip trainees not only with references and a proven track record in the classroom, but might also offer the possibility of further work.
These issues are outside the terms of reference of the commission of inquiry, and far more substantial than the short-term fix announced in February's budget.
Despite its references to Brahms's Fourth Symphony, it felt a mere squib when set alongside two far more substantial Adès compositions: his Polaris and the even longer Tevot.
More substantial!" Pavarotti said.
Or something more substantial?
It is time for something more substantial.
The markets had wanted something more substantial.
More substantial progress may take a generation.
Today their resources are more substantial.
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