The phrase "more substantial negative" is grammatically correct and can be used in written English.
It is often used to describe a negative aspect or consequence that is significant or impactful. Example: While there were some minor issues with the project, the more substantial negative was the lack of funding, which ultimately led to its failure.
The fact that this tragedy occupied front pages for a long stretch was evidence that there wasn't something more substantial and negative for editors and the public to fixate on.
Additionally, when mutations occur in E100 (E100K, E100K), the resulting mutant proteins present less negative charge than WT SOD1; the E100K mutant shows a more substantial decrease in negative charge and significantly higher aggregation potential when compared with E100G (P = 0.016).
Consequently, the negative control over glycolysis exerted by the pyruvate dehydrogenase complex was found to be more substantial than the negative control of the pyruvate transportation step.
It has the important effect of enforcing greater polymorphism (strictly, a higher effective allele number) on the clonal population than the sexual population, thereby creating a more substantial opportunity for negative interactions between co-alleles at single loci.
With the passing of time this correlation attenuates or becomes negative as a more substantial and authentic form of PTG develops.
"When everybody is negative, the upside is more substantial," Mr. Cornell says.
A poll of economists by the Centre for Macroeconomics, conducted before the referendum, found that more than 80% agreed that there would be substantial negative long-term consequences for the UK's financial sector following a Brexit.
If the elderly are given less support, there will be a negative effect on the state, requiring more substantial services later, costing more money and adding to a vicious cycle.
"This loss coupled with ongoing negative publicity may well have a far more substantial impact on the Toyota brand that should be of much greater concern to the automaker," Mr. Lebovits said.
In conclusion, we found that comorbidity was present in more than one-third of CRC patients and had a substantial negative impact on prognosis.
