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Although the changes in CVD risk factors during the short period of follow-up in this study were small, they occur on a background of increased CVD risk (21), and their determinants may over time lead to a more substantial deterioration of cardiovascular risk in diabetic subjects.
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This research has revealed that more than half of those waiting for joint replacement experienced substantial deterioration in HRQoL.
Third, our observations were made in a 2-year follow-up study, whereas the previous studies 18 19 investigated function over a period of 9 12 years, in which deterioration of physical function is likely to be far more substantial.
More substantial!" Pavarotti said.
Or something more substantial?
It is time for something more substantial.
The markets had wanted something more substantial.
More substantial progress may take a generation.
Today their resources are more substantial.
Her second coming is more substantial.
Sometimes the work is more substantial.
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