Sentence examples for more substantial defect from inspiring English sources

We next monitored the accumulation of RAD51 foci following irradiation and found a more substantial defect in INO80-depleted cells (Fig 2B).

However, various features of the disorganized cortex indicated a more substantial defect of cortical layering (Caviness and Rakic 1978; Rakic and Caviness 1995).

Proteasomes from this strain grow at the permissive temperature were proteolytically active but migrated faster than 26S holoenzymes suggesting a more substantial defect than merely loss of labile Rpn12.

The differences in bacterial burdens between the strains producing the two different mutated versions of P66 indicate that there is a more substantial colonization defect in the BDel202 208 mutant.

Surprisingly, our own more detailed analyses did not reveal any substantial defect of osteoclast-specific gene expression in PLCγ2−/− cultures, and the expression of NFATc1 was not at all affected by the PLCγ2 mutation (Fig. 4b).

The emirate of Saruhan offered a more substantial force of 6,000 men in the summer of 1346, but instead of fighting, they plundered Thrace and then defected to join Kantakouzenos' army.

These changes are much more substantial compared to the change of the parameter β 1. X-irradiation triggers the generation of point defects in silicon, which act as stoppers for dislocation motion.

This would explain that in DCM only those cells exposed to more substantial and continuous physical stress (like cardiomyocytes) develop the disease and with late onset, while in the progerias the defects are systemic and/or appear earlier.

More substantial!" Pavarotti said.

Or something more substantial?

The markets had wanted something more substantial.