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In contrast, for sirolimus, the change in mean apparent metabolic clearance (CL/ fm) was more substantial, decreasing 3.2-fold with ketoconazole treatment and resulting in an increase in mean half-life from 75 to 113 h.
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Thermally stressed corals grew less than controls, but corals without shading experienced a more substantial decrease in growth compared to those under 50% or 75% shade.
An even more substantial decrease was observed at site C, where taxon richness declined from 7.3 ± 0.4 before construction to 2.8 ± 0.7 during construction, and 2.8 ± 0.8 after construction (df = 2, F = 46.73, p < 0.001; Fig. 4b).
To evaluate connections between cAMP and A2AR in our experiments, we analyzed cAMP levels in agonist (CGS21680) and antagonist (ZM241385) treated cells and found a modest increase in the former and a more substantial decrease in the latter (Figure 5).
However, there is a more substantial decrease in average percent participation for students in the "D" and "F" grade ranges.
However, Y602F and Y779F showed more substantial decreases than the other mutants except Y596F and K653R (Fig. 1B).
FDT showed a more substantial decrease in both mean IgG and HI titers (p = 0.003 and p = 0.03, respectively).
A more substantial decrease was seen in the GMIs, most likely because intensities were extremely high in the early period of the study.
A more substantial decrease in Dicer protein levels were seen in SKBR3 cells after exposure to desferrioxamine (0.1 mM) for 48 h.
For FDT, vaccine a slight decrease in mean IgG titer (1.4-fold, p = 0.08) together with a more substantial decrease in HI titer (2.3-fold, p = 0.01) was found.
For CFA, a slow decrease was seen in prevalence from 53.3% in survey 1 to 44.9% in survey 5, whereas a more substantial decrease was seen for the GMIs (reduction by 56%).
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