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This decline in prescribing continued until the publication of the WHI in 2002, after which a more substantial decline of 18% per quarter was observed.
Cluster 5 showed a profile characterised as a small continuous decline until 5 days after birth followed by a more substantial decline to 173 days after birth.
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"However, a failure to negotiate could substantially worsen sentiment, triggering a material correction in asset prices, a house price downturn, and more substantial declines in investment and consumption spending.
"These markets are going to experience more substantial declines in the coming year," says Zandi. "Gauging the bottom is a very intrepid affair and the job market is very important to recovery".
Their results predict rising sea temperatures will alter reef fish community structure by causing more substantial declines in cardinalfish populations than in the damselfish populations.
The more substantial declines in PSA and improvements in survival with abiraterone acetate and enzalutamide validate this principle.
"In most of our markets we now expect more substantial sales declines than previously estimated".
The DPM has also reported more substantial hemoglobin declines among black patients [ 17].
SSI are preventable events and can be reduced with low-cost bundles of interventions, and reassuring staff and surgeons about compliance and engagement with multiple interventions may result in even more significant declines, resulting in substantial cost savings.
Apathy appears to have spread beyond politics, to knowledge more generally, with a substantial decline in the number of Americans who regularly read a newspaper or a book.
MCI involves more substantial cognitive and memory decline than normal aging and represents a significant risk factor for development of dementia.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com