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A few variables (age at menarche, birth weight and waist-to-hip ratio) had smaller RDRs, consistent with more substantial attenuation of estimates (RDRs 0.44-0.50).
Most other quantitative variables had RDRs in the range 0.66-0.86, consistent with slight to moderate attenuation, with the exceptions of age at menarche (RDR = 0.44, 0.33-0.55), birth weight (0.59, 0.50-0.67) and waist-to-hip ratio (0.50, 0.35-0.66), for which more substantial attenuation is likely.
Excluding these individuals resulted in slight attenuation of the OR for any enthesophyte in HBM cases compared with controls (OR 2.78 [95% CI 1.81 4.27], P < 0.001) and a more substantial attenuation of the OR for moderate enthesophytes (OR 3.10 [95% CI 1.86 5.18], P < 0.001).
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We used well validated questionnaires, and the Nurses Health Study III cohort comprised health professionals who are likely to be more familiar with health related terminology than the general population, minimizing concern for measurement errors and substantial attenuation.
To avoid substantial attenuation of the results, keeping the case groups relatively free from false positives is much more important than is avoiding some pollution of the large non-case group by (a relative low fraction of) false negatives.
More substantial!" Pavarotti said.
Her second coming is more substantial.
The markets had wanted something more substantial.
More substantial progress may take a generation.
Today their resources are more substantial.
It is time for something more substantial.
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