More responsive and efficient surveillance and control can prevent additional human disease, decrease reliance on more substantial control activities later in the season, and reduce indirect costs from medical expenses and productivity loss.
In the non-GIST group, this PFS is in the range of other agents considered active in STS, and may predict for more substantial first line activity.
Much more substantial improvement in activity would be needed (P1 was in fact set at 60%, expecting a PFS of approximately 10 months) before embarking onto a randomised phase III trial.
For enzymatic antioxidants, salt stress resulted in insignificant increases in SOD and APX activity but more substantial decreases in CAT and POX activity (1.3 and 6.2-fold, respectively) in cultivated tomato.
The much more substantial changes in reporter activity as a consequence of LY294002 treatment were, however, reflected in reduced expression of both HIF-1α and CA-9.
Taken together, this suggest that ParkFit was a safe intervention but that the programme needs to be adjusted to achieve more substantial increases in physical activity that translate into tangible health improvements.
Leonard et al. (1997) have pointed out, by reviewing studies on the factorial approach validated by DLW and HR methods, that underestimation with the factorial approach is more substantial at moderate to high activity levels than at very low activity levels.
One of our speculations is that the observed brain regions differ in metabolic functional activity, especially in growing animals, and higher activity may require more substantial exchanges of nutrition and metabolites.
Taken together these data suggest that both GXP79580 and GXP641910 regions contribute to EWS-FLI-1 mediated IGF1 promoter activity, although a more substantial contribution is made by the GXP79580 region.
Even if she had more substantial accolades during her lifetime, surely her activities and personal taste merited this small attention.
