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The eEF1Bα and eEF1BΔ subunits possess guanine nucleotide-exchange activity, whereas the eEF2Bγ subunit is thought to have a more structural role, tethering the complex to the membrane of the endoplasmic reticulum.
The different dynamics exhibited by chromosomal condensin complexes may reflect the coexistence of both an enzymatic and a more structural role.
Hence, the current view is that clathrin fulfills a primarily scaffolding/organizational role in yeast, while it mediates a more structural role (in shaping the vesicle) in mammalian cells.
This result is important, because it suggests a division of labor, in which Red1 has a more structural role both in organizing cohesin into linear, continuous arrays and in recruiting Hop1, while Hop1 may be more specialized for signal transduction and stimulating Spo11 activity.
The more severe cognitive deficits of SynII−/− mice also correlate with more intense impairments in the hippocampal short-term-plasticity than SynI−/− KO mice [24] and are in line with the idea that SynII plays a more structural role than SynI in nerve terminal physiology [15].
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Kinesins travel towards the plus or minus end of MTs, or perform more structural roles in MT organization and stability [ 9].
This data supports a more direct structural role for QIL1 in MICOS stability, suggesting a scenario that would be more consistent with QIL1 being a component of the MICOS complex rather than being indirectly involved, for example, in promoting cardiolipin production.
Interestingly, main-chain hydrogen bonds are lacking between βD and βE; therefore, a more important structural role could be hypothesized for this water molecule, which could help to keep together the walls of P2 across this structural gap.
These data support a more direct structural role for QIL1 in MICOS stability.
The other region of the loop (Gly217 Pro221) may bear a more distinct structural role.
Notably, we have shown that QIL1 does not affect cardiolipin levels or species distribution, supporting a more direct structural role for QIL1 in MICOS complex maturation.
More suggestions(15)
more modulatory role
more formal role
more structural diversity
more diverse role
more substantial role
more unifying role
more structural reorganisation
more amplification role
more public role
more modest role
more constructive role
more prominent role
more commanding role
more female role
more structural firm-level
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