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This precluded a further meta-analysis, but suggested that Chinese trials require a more stringent study design.
Therefore a further and more stringent study of psychological interventions in IBD patients to enhance quality of life and reduce anxiety and depression is warranted.
In addition, more stringent study designs are required to better account for a past history of joint injury as a potential confounder among studies examining the relationship between physical activity and knee OA.
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More stringent studies, especially double-blinded randomized clinical trials, are needed in different countries around the world.
Second, to maximize the potential to be applied for more stringent clinical study, new and reliable methods for measuring autophagy in clinical samples need to be developed.
Like many other pharmacovigilance data analyses, our proposed associations between ADEs and high-dimensional drug interactions need further molecular experimental validation, and using a more stringent pharmacoepidemiological study design and alternative databases.
Because of the biological nature of mAb biotherapeutics, regulatory agencies demand more stringent clinical studies for biotherapeutics than for small molecule drugs due to the potential for adverse immune responses or organ-specific effects [ 2].
Minimal cardiac abnormalities should be considered as exclusion criteria together with more stringent cardiac survey in programming future studies.
The definition of a correctly mapped read introduced in this study is more stringent than for previous studies, because it takes into account the correctness of the alignment (length, number, and type of edit operations).
Such high risk products require more stringent regulation, including studies of clinical performance to determine their efficacy in the target population.
The standards for selection were much more stringent and only studies with controls or interrupted time series with explicit entry and quality criteria were considered and finally only four studies were included.
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