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In fact, 12 was an inhibitor to GGTase-I, indicating more stringent specificity for the isoprenoid substrates for that enzyme.
Thus, as the criteria for calling a test result positive are made more stringent, specificity improves at the expense of sensitivity.
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It is becoming increasingly evident that certain viral proteases have more stringent sequence specificity.
These less conserved determinants of MHC I confer a more stringent allele specificity for KIRs than for LIR receptors.
However, equivalent applications for studying development in multicellular eukaryotes require novel tools with more stringent sequence specificity and increased versatility, due to higher genomic complexity, as well as a critical efficiency threshold to enable routine applications.
Thus the low activity of rHhoB might also reflect, similarly to E. coli DegS [ 9], a more stringent substrate specificity, a function as a chaperone rather than a protease, a requirement for as yet unidentified cofactors, such as allosteric activators [ 17– 19], or a need for the formation of a hetero-oligomeric complex.
The galling genus Kladothrips arose as recently as 6 Mya and represents the least uncertain shift to more stringent host-specificity by thrips and specialisation solely on Acacia.
Using the more stringent criteria (high specificity) the number of healthy controls with positive DNA detection decreased to 4 of 22 individuals (18%), whereas for patients with polyps 22 of 49 patients (45%) were considered positive (p = 0.02).
Certain pro-apoptotic interventions might still require a more stringent level of specificity.
For simplicity, only one control group image is shown, and as injection of a control morpholino is a more stringent test of morpholino specificity, these images are shown.
For example, more stringent cancer cell specific promoters have been utilized to control E1A expression for improved specificity of CRAD replication in cancer cells [5] [7].
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