Sentence examples for more stringent sequence from inspiring English sources

It is becoming increasingly evident that certain viral proteases have more stringent sequence specificity.

Since the increase in order of the Markov model implies that a more stringent sequence property is used to calculate compositional differences, a higher order model will in general give a more accurate representation of the sequence than a lower order one.

Whereas redundancy removal caused by substrings and repeated sequences is essential, introduction of a more stringent sequence identity threshold is not.

In addition, there is more stringent sequence conservation in the 5' end of homologous miRNAs than in the 3' end [ 36]. 5) Number of nucleotides in the miRNA 5' region involved in G U base pairs.

However, equivalent applications for studying development in multicellular eukaryotes require novel tools with more stringent sequence specificity and increased versatility, due to higher genomic complexity, as well as a critical efficiency threshold to enable routine applications.

Mecham et al. have suggested that the lack of concordance in cross-platform microarray comparisons may be caused by a reliance on gene annotations without more stringent sequence-oriented matching of probes [ 23].

By using more stringent sequence-analysis criteria in a quality-improving protocol, we removed contaminated tags matched to cloning linkers, vectors, and simple repeats, and obtained 68,462 unique empirical tags; this number is 21 tags less than the previous dataset due to more stringent filters.

We also validated the performance of MD on a subset of our set that was obtained using a more stringent criterion for sequence uniqueness, i.e., for HSSP-values<0.

For the per-protein analysis, we used a sequence-unique subset of DisProt that consisted of 205 proteins with at least one long (>30 residues) disordered region, and again, validated the results on a set that was created using the more stringent criterion for sequence uniqueness.

When we applied a more stringent similarity threshold (sequence identity ≥ 95%, alignment coverage ≥ 95%), the number of poplar FLcDNAs matching to the genome was only slightly reduced to 4,487 (96.2%).

In addition, the databases searched were from 2004, several years out of date, and a more stringent method of sequence contig construction was used in this work (see methods).